Mageb4, a testis-specific gene, is dispensable for mouse spermatogenesis
نویسندگان
چکیده
منابع مشابه
A Novel Testis-Enriched Gene Spata33 Is Expressed during Spermatogenesis
With an increasing incidence of male idiopathic infertility, identification of novel genes involved in spermatogenesis is an important aspect for the understanding of human testicular failure. In the present study, we have identified a novel gene Spata33, also called as 4732415M23Rik or C16orf55, which is conserved in mammalian species. Spata33 was predominantly expressed in the postpartum and ...
متن کاملMAFB is dispensable for the fetal testis morphogenesis and the maintenance of spermatogenesis in adult mice
The transcription factor MAFB is an important regulator of the development and differentiation of various organs and tissues. Previous studies have shown that MAFB is expressed in embryonic and adult mouse testes and is expected to act as the downstream target of retinoic acid (RA) to initiate spermatogenesis. However, its exact localization and function remain unclear. Here, we localized MAFB ...
متن کاملIdentification of a novel testis-specific gene and its potential roles in testis development/spermatogenesis.
AIM To identify and characterize a novel gene with potential roles in testis development and spermatogenesis. METHODS A cDNA microarray was constructed from a human testis large insert cDNA library and hybridized with probes of human or mouse adult and fetal testes. Differentially expressed genes were isolated and sequenced. RT-PCR was used to test the tissue distribution of the genes of inte...
متن کاملMouse BAZ1A (ACF1) Is Dispensable for Double-Strand Break Repair but Is Essential for Averting Improper Gene Expression during Spermatogenesis
ATP-dependent chromatin remodelers control DNA access for transcription, recombination, and other processes. Acf1 (also known as BAZ1A in mammals) is a defining subunit of the conserved ISWI-family chromatin remodelers ACF and CHRAC, first purified over 15 years ago from Drosophila melanogaster embryos. Much is known about biochemical properties of ACF and CHRAC, which move nucleosomes in vitro...
متن کاملFunctional compensation for the loss of testis-specific poly(A)-binding protein, PABPC2, during mouse spermatogenesis
Mouse testes contain several isoforms of cytoplasmic poly(A)-binding proteins (PABPCs), including ubiquitous PABPC1 and testis-specific PABPC2/PABPt. PABPC2 is characterized by its absence from translationally active polyribosomes and elongating spermatids. To elucidate the function of PABPC2 in spermatogenesis, we produced mutant mice lacking PABPC2. The PABPC2-null mice showed normal fertilit...
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ژورنال
عنوان ژورنال: Reproductive and Developmental Medicine
سال: 2020
ISSN: 2096-2924
DOI: 10.4103/2096-2924.296546